| Title | Date | Views | Brief Description |
|---|
| Hepatic stellate cell transdifferentiation: Pro-fibrogenic effectors |
2011 |
1478 |
Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimulates... |
| Role of nonmuscle myosin II isoforms in hepatic stellate cell activation |
2009 |
492 |
The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent HSC... |
| Effects of S-adenosyl-L-methionine on collagen expression in activated hepatic stellate cells |
2009 |
555 |
Liver fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components, which can disrupt the normal liver microcirculation and lead to injury. Unresolved, hepatic fibrosis can progress to cirrhosis, an end-state liver disea... |