Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Mohammed Al-Huniti, Research Scientist (Creator)
Mitchell Croatt, Assistant Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Conditions for the first palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids to give the desired polyenes in good yields are presented. The reactions proceed under mild conditions using either a Pd(0) or Pd(II) catalyst and tolerate a variety of aryl and aliphatic substitutions. Unique aspects of the reaction include the requirement of phosphines, water, and a polyene adjacent to the carboxylic acid.

Additional Information

Organic Letters 2018, 23, 7375-7379
Language: English
Date: 2018
Polyenoic Acids, Protodecarboxylation

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