Probing the Role of the Mycosamine C2'-OH on the Activity of Amphotericin B
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Mitchell Croatt, Assistant Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: A synthetic route to a mycosamine donor was designed and provided access to a set of AmB derivatives targeted to probe the effect of the C2'-OH. It was determined that the configuration of the C2'-position is inconsequential but that O-methylation of this alcohol was deleterious to its mode of action. Additionally, the analog incorporating a mycosamine derivative from the enantiomeric series was devoid of activity.
Probing the Role of the Mycosamine C2'-OH on the Activity of Amphotericin B
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Additional Information
- Publication
- Language: English
- Date: 2011
- Keywords
- chemistry, biochemistry, mycosamine C2’ –OH, amphotericin B