Selective Formation of 1,5-Substituted Sulfonyl Triazoles Using Acetylides and Sulfonyl Azides

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Mitchell Croatt, Assistant Professor (Creator)
Maria Elena Meza-Avina, Research Scientist (Contributor)
The University of North Carolina at Greensboro (UNCG )
Web Site:

Abstract: The reaction of acetylides with sulfonyl azides was found to selectively form 1,5-substituted sulfonyl triazoles. This reaction thus provides access to the regioisomeric product as compared to the popular copper-catalyzed azide–alkyne cycloaddition. The reaction is efficient and selective with a variety of alkyne sources and sulfonyl azides and can incorporate an additional electrophile to yield 1,4,5-trisubstituted sulfonyl triazoles.

Additional Information

Language: English
Date: 2011
chemistry, biochemistry, sulfonyl triazoles, acetylides, solfonyl aziders

Email this document to