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Synthesis and Pharmacology of 1-Methoxy Analogs of CP-47,497

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Dow P. Hurst, Research Scientist (Creator)
Patricia H. Reggio, Professor and Department Head (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Three 1-methoxy analogs of CP-47,497 (7, 8 and 19) have been synthesized and their affinities for the cannabinoid CB1 and CB2 receptors have been determined. Although these compounds exhibit selectivity for the CB2 receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor.

Additional Information

Publication
Bioorganic and Medicinal Chemistry, 18, 5475-5482
Language: English
Date: 2010
Keywords
CB, CB receptor, CB2 receptor, nontraditional cannabinoids, 1-Methoxy cannabinoids