Liposomal formulation of amphiphilic fullerene antioxidants
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Anthony Dellinger (Creator)
- Christopher Kepley, Associate Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Novel amphiphilic fullerene[70] derivatives that are rationally designed to intercalate in lipid bilayers are reported, as well as its vesicular formulation with surprisingly high loading capacity up to 65% by weight. The amphiphilic C70 bisadduct forms uniform and dimensionally stable liposomes with auxiliary natural phospholipids as demonstrated by buoyant density test, particle size distribution, and 31P NMR. The antioxidant property of fullerenes is retained in the bipolarly functionalized C70 derivative, amphiphilic liposomal malonylfullerene[70] (ALM), as well as in its liposomal formulations, as shown by both electron paramagnetic resonance (EPR) studies and in vitro reactive oxygen species (ROS) inhibition experiments. The liposomally formulated ALM efficiently quenched hydroxyl radicals and superoxide radicals. In addition, the fullerene liposome inhibited radical-induced lipid peroxidation and maintained the integrity of the lipid bilayer structure. This new class of liposomally formulated, amphipathic fullerene compounds represents a novel drug delivery system for fullerenes and provides a promising pathway to treat oxidative stress-related diseases.
Liposomal formulation of amphiphilic fullerene antioxidants
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Created on 8/19/2019
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Additional Information
- Publication
- Bioconjugate Chemistry. 2010; 21:1656-61.
- Language: English
- Date: 2010
- Keywords
- fullerenes, liposomes, novel fullerene delivery