Evidence for human mast cell nonreleaser phenotype

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Christopher Kepley, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Mast cells and basophils express high amounts of Fc?RI. In basophils the concentration of anti-IgE or antigen required for maximal histamine release through Fc?RI varies among donors, a concept termed “releasability.” Some donors fail to release histamine in response to any concentration of IgE-mediated stimulus (nonreleaser)1, 2, 3, 4 and were subsequently found to lack the protein tyrosine kinase Syk.5 Although the nonreleaser phenoytpe is common (ie, present in 10% to 20% of all donors), it is not known whether mast cells exhibit a similar IgE-mediated nonresponsiveness. We report here a lung mast cell preparation that did not respond to IgE-mediated stimuli.

Additional Information

Journal of Allergy and Clinical Immunology 2003; 112:457-9.
Language: English
Date: 2003
letter to the editor, mast cells, basophils, nonreleaser phenotype

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