Studies examining the anti-aging effects of fullerenes

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Ashley R. Turner (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Christopher Kepley

Abstract: Research on aging has been invigorated by recent findings suggesting certain mutations in various invertebrate models (yeast, worms, and flies) can slow down aging and improve healthspan. Reactive Oxygen Species (ROS) production and manipulation of the nutrient-sensing [mammalian (originally) or mechanistic target of rapamycin] mTOR signaling pathway have all been linked to aging and age-related diseases. Thus, identifying ways to interfere in these pathways may represent a promising avenue to increase longevity and improve healthspan in mammals. Fullerenes are a class of nanomaterials best known for their ability to significantly extend mammalian lifespan and cognitive function as shown in both mice and rats. Thus, the goal of this proposal is to determine possible mechanisms of how fullerenes extend lifespan focusing on mTOR signaling pathways and anti-oxidant capabilities to slow down aging and improve healthspan.

Additional Information

Language: English
Date: 2017
Aging, Antioxidants, Fullerenes, mTOR
Aging $x Prevention
Fullerenes $x Therapeutic use
Antioxidants $x Therapeutic use

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