Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-A And -B Messenger Ribonucleic Acid And Protein
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Dr.. Chishimba Nathan Mowa, Associate Professor (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
Abstract: Body tissues are traditionally classified as estrogen targets based on both the response to the hormone and the presence of estrogen receptors (ERs). We undertook the study on expression of ERff and ERb in the penis to identify compartments/cells responsive to estrogen, using immunohistochemistry, Western blotting, in situ hybridization, and RT-PCR analyses. Expressions of ERa and ERb in the rat penis were age dependent at both mRNA and protein levels, with the most intense signals being observed during the perinatal period and declining thereafter with age. Initial signals (fetal d 17) of ERff were localized to the mesenchyme and subepithelial stroma and later (postnatal d 2) to the corpus spongiosus, corpus cavernosus, and urethral epithelia. ERb was initially detected by postnatal d 2 and was localized diffusely in corpus spongiosus and cavernosus in immature rats. In the adult, both ERs were concentrated largely to the urethral epithelia and vascular and neuronal structures. The present study provides the first evidence for ER expression in the penis. Thus, our data add the penis to the list of estrogen-responsive tissues in males and provide a base and insight for future studies aimed at investigating a functional role of estrogen in the penis, especially in development.
Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-A And -B Messenger Ribonucleic Acid And Protein
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Additional Information
- Publication
- Subrina Jesmin, Chishimba N. Mowa, Naoyuki Matsuda, Alaa-Eldin Salah-Eldin, Hiroko Togashi, Ichiro Sakuma, Yuichi Hattori, And Akira Kitabatake (2002) "Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-A And -B Messenger Ribonucleic Acid And Protein." Endocrinology 143(12):4764-4774 Version of Record Available At www.academic.oup.com [DOI: 10.1210/en.2002-220628]
- Language: English
- Date: 2002
- Keywords
- estrogen receptor, gonad, male, female, penis, ribonucleic acid