| Antagonism Of Endothelin Action Normalizes Altered Levels Of VEGF And Its Signaling In The Brain Of Stroke-Prone Spontaneously Hypertensive Rat |
2007 |
917 |
Stroke-prone spontaneously hypertensive rats (SHRSP) often suffer from spontaneous stroke, in part, due to abnormalities in the cerebrovasculature. Here, we investigate the profile of key angiogenic factors and their basic signaling molecules in the ... |
| Characterization Of Vascular Endothelial Growth Factor (VEGF) “In The Uterine Cervix Over Pregnancy: Effects Of Denervation And Implications For Cervical Ripening |
2004 |
1396 |
Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix- related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in ... |
| Delineation Of VEGF-Regulated Genes And Functions In The Cervix Of Pregnant Rodents By DNA Microarray Analysis |
2008 |
1376 |
Background: VEGF-regulated genes in the cervices of pregnant and non-pregnant rodents (rats and mice) were delineated by DNA microarray and Real Time PCR, after locally altering levels of or action of VEGF using VEGF agents, namely siRNA, VEGF recept... |
| Dual Blockade Of Endothelin Action Exacerbates Up-Regulated VEGF Angiogenic Signaling In The Heart Of Lipopolysaccharide-Induced Endotoxemic Rat Model |
2016 |
634 |
Aims: Sepsis is a cluster of heterogeneous syndromes associated with progressive endotoxemic developments, ultimately leading to damage of multiple organs, including the heart. However, the pathogenesis of sepsis-induced myocardial dysfunction is sti... |
| Effects Of Protease Activated Receptor (PAR)2 Blocking Peptide On Endothelin-1 Levels In Kidney Tissues In Endotoxemic Rat Model |
2014 |
863 |
Aims: Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sep... |
| Endothelin Antagonism Normalizes VEGF Signaling And Cardiac Function In STZ-Induced Diabetic Rat Hearts |
2007 |
589 |
Abnormal alterations in cardiac expression of vascular endothelial growth factor (VEGF) as well as its receptors and impairment in the development of coronary collaterals have recently been reported in diabetic subjects. However, the presence of phar... |
| Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-A And -B Messenger Ribonucleic Acid And Protein |
2002 |
800 |
Body tissues are traditionally classified as estrogen targets based on both the response to the hormone and the presence of estrogen receptors (ERs). We undertook the study on expression of ERff and ERb in the penis to identify compartments/cells res... |
| Expression Of Pituitary Adenylate Cyclase Activating Peptide In The Uterine Cervix, Lumbosacral Dorsal Root Ganglia And Spinal Cord Of Rats During Pregnancy |
2006 |
590 |
The uterine cervix is highly innervated by the sensory nerves containing neuropeptides which change during pregnancy and are regulated, in part, by estrogen. These neuropep- tides act as transmitters both in the spinal cord and cervix. The present st... |
| Expression Of Steroidogenic Enzymes And Synthesis Of Sex Steroid Hormones From DHEA In Skeletal Muscle Of Rats |
2007 |
1104 |
The functional importance of sex steroid hormones (testosterone and estrogens), derived from extragonadal tissues, has recently gained signi?cant appreciation. Circulating dehydroepiandrosterone (DHEA) is peripherally taken up and converted to testos... |
| Gonadal Hormones And Frontocortical Expression Of Vascular Endothelial Growth Factor In Male Stroke- Prone, Spontaneously Hypertensive Rats, A Model For Attention-Deficit/Hyperactivity Disorder |
2004 |
571 |
Attention-deficit/hyperactivity disorder (AD/HD) is a common pediatric behavioral disorder associated, in part, with male preponderance and reduced regional cerebral blood flow (rCBF). However, mechanism(s) underlying male preponderance and reduced r... |
| Landiolol Hydrochloride Ameliorates Acute Lung Injury In A Rat Model Of Early Sepsis Through The Suppression Of Elevated Levels Of Pulmonary Endothelin-1 |
2016 |
994 |
Among the dysfunctions and pathologies associated with sepsis, the underlying molecular mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood. Endothelin (ET)-1, a potent vasoconstrictor and pro-inflammatory peptide, is known to ... |
| The Penis: A New Target And Source Of Estrogen In Male Reproduction |
2006 |
5514 |
In the past decade, interest and knowledge in the role of estrogen in male reproduction and fertility has gained significant momentum. More recently, the cellular distribution and activity of estrogen receptors (a and ß)(ER) and aromatase (estrogen s... |
| Postpartum Cervical Repair In Mice: A Morphological Characterization And Potential Role For Angiogenic Factors |
2015 |
1671 |
The cervix undergoes marked mechanical trauma during delivery of the baby at birth. As such, a timely and complete tissue repair postpartum is necessary to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarr... |
| A Proteomic Profile Of Cervical Remodeling In Mice During Early And Late Pregnancy |
2014 |
325 |
Objective: Decipher mechanisms that underlie cervical remodeling (CR) during pregnancy. Design and population: Examine the proteomic profile of mice cervices in early and late pregnancy and verify data generated using Western Blot and real time PCR a... |
| Substance P In The Uterine Cervix, Dorsal Root Ganglia And Spinal Cord During Pregnancy And The Effect Of Estrogen On SP Synthesis |
2003 |
2068 |
Prior to parturition the non-pliable uterine cervix undergoes a ripening process (“softens” and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence ... |
| Vascular Endothelial Growth Factor Induces Growth Of Uterine Cervix And Immune Cell Recruitment In Mice |
2013 |
1481 |
Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on ute... |