Examining the Effect of Tks5 Sh3 Domain Mutations on Invadopodia Localization and Development in Cancer Cells

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Kelley Whitaker (Creator)
Institution
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/
Advisor
Darren Seals

Abstract: Metastasis, the process by which cancers spread from their site of origin to distant anatomic sites, accounts for about ninety percent of all cancer deaths. Metastasis occurs when cancer cells acquire the invasive behaviors necessary for breaching tissue boundaries. Invadopodia, actin-rich cell surface protrusions, stimulate metastasis by enabling adhesion, motility, and extracellular matrix remodeling by cancer cells. Src tyrosine kinase and its substrate Tks5 localize to invadopodia and regulate their development. Tks5 is composed of a PX domain followed by five SH3 domains. While the lipid-binding PX domain is essential for Tks5 dependent invadopodia localization and development, the five protein-binding SH3 domains of Tks5 are less defined.

Additional Information

Publication
Honors Project
Whitaker, K.E. (2015). Examining the Effect of Tks5 Sh3 Domain Mutations on Invadopodia Localization and Development in Cancer Cells. Unpublished honors thesis. Appalachian State University, Boone, NC.
Language: English
Date: 2015
Keywords
inradopodia, TKS5, SH3 domain, cancer cell metastasis, cancer cells

Email this document to