Seals, Darren

asu

There are 5 item/s.

TitleDateViewsBrief Description
Examining the Effect of Tks5 Sh3 Domain Mutations on Invadopodia Localization and Development in Cancer Cells 2015 1131 Metastasis, the process by which cancers spread from their site of origin to distant anatomic sites, accounts for about ninety percent of all cancer deaths. Metastasis occurs when cancer cells acquire the invasive behaviors necessary for breaching ti...
The Role Of TKS5 SH3 Domains In Invadopodia Development And Activity 2016 7331 One mechanism by which cancer cells metastasize is through the formation of actin-rich structures called invadopodia. Tks5 is a Src tyrosine kinase substrate and scaffolding protein necessary for invadopodia formation and associated extracellular ma...
The Cytotoxic Effects Of Vesicular Stomatitis Virus On THP-1 Macrophages 2018 812 Cancer cells do not act autonomously. The interaction between cancer cells and other ‘normal’ cell types creates a tumor microenvironment conducive for the growth and progression of the disease. Tumor-associated macrophages (TAMs) are among the immun...
Blocking M1 Repolarization Of M2 THP-1 Macrophages Through Inhibition Of The Type I Interferon Response By Vesicular Stomatitis Virus 2021 173 Matrix protein mutant strains of VSV, such as rM51R-M virus, are currently being investigated as oncolytic agents due to their ability to target and kill cancer cells while also stimulating innate immunity. We seek to examine the ability of rM51R-M v...
Wild-Type And Matrix Protein Mutant Strains Of Vesicular Stomatitis Virus Differentially Modulate Podosome Development In M1 And M2 Macrophage Populations 2021 19 Macrophages of the tumor microenvironment form cytoskeletal adhesion structures called podosomes that facilitate invasive behavior of cancer cells through degradation of extracellular matrix proteins. This study investigates whether macrophage podoso...