Seals, Darren

asu

There are 7 item/s.

TitleDateViewsBrief Description
The Role Of TKS5 SH3 Domains In Invadopodia Development And Activity 2016 8054 One mechanism by which cancer cells metastasize is through the formation of actin-rich structures called invadopodia. Tks5 is a Src tyrosine kinase substrate and scaffolding protein necessary for invadopodia formation and associated extracellular ma...
Blocking M1 Repolarization Of M2 THP-1 Macrophages Through Inhibition Of The Type I Interferon Response By Vesicular Stomatitis Virus 2021 662 Matrix protein mutant strains of VSV, such as rM51R-M virus, are currently being investigated as oncolytic agents due to their ability to target and kill cancer cells while also stimulating innate immunity. We seek to examine the ability of rM51R-M v...
The Effects Of Malnutrition And Plasmodium Chabaudi Infection On Innate Mucosal Immunity In The Gut 2022 157 The overlap of malnutrition and malaria results in high morbidity and mortality. We aimed to evaluate how malaria infection affects gut mucosal immunity during moderate malnutrition. We used a specialized diet common in malaria endemic regions that i...
Examining the Effect of Tks5 Sh3 Domain Mutations on Invadopodia Localization and Development in Cancer Cells 2015 1220 Metastasis, the process by which cancers spread from their site of origin to distant anatomic sites, accounts for about ninety percent of all cancer deaths. Metastasis occurs when cancer cells acquire the invasive behaviors necessary for breaching ti...
Wild-Type And Matrix Protein Mutant Strains Of Vesicular Stomatitis Virus Differentially Modulate Podosome Development In M1 And M2 Macrophage Populations 2021 206 Macrophages of the tumor microenvironment form cytoskeletal adhesion structures called podosomes that facilitate invasive behavior of cancer cells through degradation of extracellular matrix proteins. This study investigates whether macrophage podoso...
Influence Of Oncolytic Vesicular Stomatitis Virus On Macrophage Phagocytosis And Breast Cancer Cell Growth In Coculture 2023 86 This study tested the hypothesis that oncolytic vesicular stomatitis virus could reprogram tumor-promoting M2 THP-1 macrophages into an M1 population capable of suppressing the growth of triple-negative breast cancer cells. While evidence of virus-de...
The Cytotoxic Effects Of Vesicular Stomatitis Virus On THP-1 Macrophages 2018 1099 Cancer cells do not act autonomously. The interaction between cancer cells and other ‘normal’ cell types creates a tumor microenvironment conducive for the growth and progression of the disease. Tumor-associated macrophages (TAMs) are among the immun...