Innovative Research Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
William N. Dudley, Professor Public Health Education (Creator)
Jennifer L. Etnier, Professor (Creator)
Vincent C. Henrich, Professor (Creator)
William B. Karper, Associate Professor (Creator)
Jeffrey Labban (Creator)
Kelly L. Rulison, Associate Professor (Creator)
Laurie Wideman, Safrit-Ennis Distinguished Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Physical activity is predictive of better cognitive performance and lower risk of Alzheimer’s disease (AD). The apolipoprotein E gene (APOE) is a susceptibility gene for AD with the e4 allele being associated with a greater risk of AD. Cross-sectional and prospective research shows that physical activity is predictive of better cognitive performance for those at greater genetic risk for AD. However, the moderating role of APOE on the effects of a physical activity intervention on cognitive performance has not been examined. The purpose of this manuscript is to justify the need for such research and to describe the design, methods, and recruitment tactics used in the conductance of a study designed to provide insight as to the extent to which cognitive benefits resulting from an 8-month physical activity program are differentiated by APOE e4 status. The effectiveness of the recruitment strategies and the feasibility of recruiting APOE e4 carriers are discussed.

Additional Information

Journal of Aging and Physical Activity
Language: English
Date: 2015
exercise, cognition, aging, brain-derived neurotrophic factor, Alzheimer’s disease, apolipoprotein E, APOE

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