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The highly preorganized ligand 2, 9-DI-(2'-PYRIDYL)-1, 10-Phenanthroline, and its complexation properties with metal ions

UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
Gregory Mercer Cockrell (Creator)
Institution
The University of North Carolina Wilmington (UNCW )
Web Site: http://library.uncw.edu/
Advisor
Robert Hancock

Abstract: The compound 2,9-di-(2’-pyridyl)-1,10-phenanthroline (DPP) has many potential uses in the fields of medicinal and environmental chemistry. The great stability possessed by complexes of DPP and heavier metal ions such as cadmium, lead, and mercury, is ideal when designing ligands for uses as fluorescence sensors or chelation therapies. This ligand, and others in its class, posses a high degree of preorganization. This means that they are designed to target specific metal ions by being in the correct conformation in its free form. UV/Vis spectroscopy was utilized to calculate stability constants with several different metal ions of varying ionic charges and radii. DPP was found to be highly selective for cadmium with a log K1 = 12.21. Other metal ions that formed very stable complexes were bismuth (log K1 = 15.72) and mercury (not measurable with available materials). Fluorescence studies were conducted and found that upon binding to cadmium, DPP has a dramatic increase in fluorescence intensity. Fluorescence studies also showed that cadmium could be detected in aqueous solution at concentrations as low as 1 x 10-10 M.

Additional Information

Publication
Thesis
A Thesis Submitted to the University of North Carolina at Wilmington in Partial Fulfillment of the Requirement for the Degree of Masters of Science
Language: English
Date: 2009
Keywords
Ligands--Synthesis, Metal ions--Analysis, Metals--Analysis
Subjects
Ligands -- Synthesis
Metal ions -- Analysis
Metals -- Analysis