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Hancock, Robert

uncw

There are 13 item/s.

TitleDateViewsBrief Description
Metal ion complexing properies [i.e. properties] of amide donating ligands 2009 3823 The present state of knowledge of the coordinating properties of polyamine ligands with pendant amide groups is reviewed. The coordinating properties of ligands of this type are largely unknown at the present time. The high basicity of amide oxygen...
Synthesis and design of fluorescence ligands to act as sensor for zinc 2009 1395 Design and synthesis of ligands to detect low concentrations of Zn2+ in various systems are being explored worldwide. The purpose of this research is to synthesize and study fluorescent sensors for Zn2+ in nervous system by utilizing CHEF (Chelatio...
Complexation of metal ions in aqueous solution by fluorescent ligands containing pyridyl groups 2009 2998 This research focused primarily on the induction of fluorescence by secondary ligands in solution. The Zn2+ ion, when complexed to fluorophoric ligands, is known to enhance the intensity of emission. With this in mind, both a fluorescence-quenching...
The removal of Cremophor® EL from paclitaxel for quantitative analysis by HPLC-UV 2009 3363 The most common technique for analysis of drug substances is high performance liquid chromatography (HPLC) using a variable wavelength detector (UV). Cremophor® EL (ethoxylated castor oil, CrEL) is a non-ionic emulsifier that is used to assist in t...
The study of 8-Hydroxyquinoline-2-Carboxyllic acid and its metal ion complexing properties 2009 3085 The metal ion coordinating properties of the ligand HQC (8-hydroxyquinoline-2- carboxylic acid) were studied by UV-visible spectroscopy and X-ray crystallography. The protonation constants of HQC were determined by monitoring absorbance of 5 x 10-5...
Metal ion complexing properties of the two-dimensional, highly preorganized ligand 1, 10-Phenanthroline-2, 9-Dicarboxylic acid 2009 1940 Preorganized ligands have proven to be important to inorganic chemistry, yielding higher stability constants and sharper metal ion selectivity than their more flexible analogs. These ligands may have important applications in the biomedical, enviro...
The highly preorganized ligand 2,9-BIS(Hydroxymethyl)-1,10-Phenanthroline, and its complexation properties with metal ions 2009 1385 Preorganization has been shown to be an important concept in inorganic chemistry. Preorganization increases the thermodynamic stability of complexes and metal ion selectivity of ligands. A ligand is more highly preorganized the more nearly it is cons...
The highly preorganized ligands 1,10-Phenanthroline-2,9-Dialdoxime and BIS-1, 10-Phenanthroline, and their complexing properties with metal ions 2009 4497 Preorganization is important in the recognition of metal ions by ligands. A ligand is more preorganized the more it is constrained as the free ligand to be in the conformation required to complex the target metal ion. Until the present time, high l...
The highly preorganized ligand 2, 9-DI-(2'-PYRIDYL)-1, 10-Phenanthroline, and its complexation properties with metal ions 2009 566 The compound 2,9-di-(2’-pyridyl)-1,10-phenanthroline (DPP) has many potential uses in the fields of medicinal and environmental chemistry. The great stability possessed by complexes of DPP and heavier metal ions such as cadmium, lead, and mercury,...
Metal ion complexing and fluorescence properties of the novel hemicycle, dipyridoacridine, with computational studies on metal ion selectivity 2009 1195 The novel hemicycle dipyridoacridine (DPA) was studied using UV/Vis spectrophotometric and 3D-fluorometric methods. The UV/Vis spectrophotometric methods resulted in a pKa2 for DPA of 4.52 + 0.06, and a pKa1 of 2.22 + 0.03. Formation constants were...
Development of a sensitive [delta]¹5 N analysis for photopigments 2009 1015 A method for the oxidation and nitrogen isotopic analysis of photopigments (chlorophyll and phaeophytin) has been developed. Homogenous single source materials (spinach and diatom culture) as well as mixed matrix (estuarine water) natural samples w...
Metal ion complexing properties of the highly preorganized ligand 1, 10-phenanthroline-2,9-dicarboxylic acid 2009 2202 Highly preorganized ligands have shown greater stability constants as well as increased metal-ion selectivities over their straight-chain analogs. These ligands show a promising future in the bioinorganic, nuclear and industrial fields as well as m...
The highly preorganized ligands 8-(2-Pyridyl) Quinoline, 2,2'-dipyridyl amine and 1,10-phenanthroline-2, 9-dicarboxylic acid, and their complexing properties with metal ions 2009 1390 Highly preorganized ligands are those that are constrained as the free ligands to be in the conformation required to complex the target metal ion. Such ligands have been shown to form more stable complexes, and display higher metal ion selectivity ...