An Algorithm for Using Hydroxyurea in Sickle Cell Disease

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Joy Curry (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Sickle Cell Disease (SCD) is an inherited blood disorder that affects many African Americans globally. This disease is characterized by acute complications from chronic anemia, episodes of painful acute on chronic vaso-occlusive pain syndrome, and organ damage. Despite optimizing Hydroxyurea (HU), these events can still occur. The purpose of the DNP project was to implement an algorithm to standardize HU for specific genotypes, particularly hemoglobin SS and hemoglobin Sß-0-thalassemia. The project aimed to increase HU prescribing and improve educational opportunities for this disease-modifying therapy to achieve the benchmark of at least 80% prescribing. The Plan-Do-Study-Act methodology was used to test change and evaluate HU prescribing. Findings from the project indicated an increase in prescribing with the use of the algorithm. The algorithm provided an evidence-based guideline for decision-making based on eligible hemoglobinopathies. Standardizing this algorithm enabled providers to increase HU prescribing and provide educational leaflets on HU to patients which, in turn, increased the interests of the participants to engage in self-management. HU is an effective way of improving the patients’ outcomes for preventing complications with SCD.

Additional Information

Publication

Other

Curry, J. E. (2021). An Algorithm for Using Hydroxyurea in Sickle Cell Disease [Doctor of Nursing Practice project report, East Carolina University College of Nursing]. The Scholarship. \r\n\r\nEnd citation: (Curry, 2021). \r\nNarrative citation: Curry (2021)

Language: English

Date: 2023

Subjects

sickle cell disease, hydroxyurea, algorithm, hemoglobin SS, and hemoglobin Sß-0-thalassemia

Email this document to