Triclosan: An Update on Biochemical and Molecular Mechanisms

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Mohammad A.,Lee,Myon-Hee Alfhili (Creator)
East Carolina University (ECU )
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Abstract: Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products.Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. Awealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularlyagainst inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action haveidentified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiologicallifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with specialemphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.

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Language: English
Date: 2019

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