Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Mia,Pipalia,Amrish,Weil,Andrew Gonzales (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Heparin-induced thrombocytopenia (HIT) type II is caused by antibody production that bind complexes between heparinand platelet factor 4 leading to platelet consumption and thrombosis. In a small subset of cases referred to as autoimmuneHIT, the antibodies activate platelets even in the absence of heparin. Refractory HIT is a type of autoimmune HIT in whichthrombocytopenia persists for weeks after heparin discontinuation and carries increased risk for thrombosis and moresevere thrombocytopenia. We present a case of refractory HIT with cerebral venous sinus thrombosis (CVST) that wassuccessfully treated with a change in anticoagulant alongside steroids and a second trial of intravenous immunoglobulin(IVIg).

Additional Information

Publication

Other

Language: English

Date: 2019

Keywords

heparin-induced thrombocytopenia, cerebral venous sinus thrombosis, IVIg, refractory HIT, autoimmune HIT

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