Prevalence, trends, outcomes, and disparities in hospitalizations for nonalcoholic fatty liver disease in the United States

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Adeyinka Charles,Samuel,Gbeminiyi Olanrewaju,Adegbala,Oluwo Adejumo (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Background: As the frequency of nonalcoholic fatty liver disease (NAFLD) continues to rise inthe United States (US) community, more patients are hospitalized with NAFLD. However, dataon the prevalence and outcomes of hospitalizations with NAFLD are lacking. We investigated theprevalence, trends and outcomes of NAFLD hospitalizations in the US.Methods: Hospitalizations with NAFLD were identified in the National Inpatient Sample(2007-2014) by their ICD-9-CM codes, and the prevalence and trends over an 8-year periodwere calculated among different demographic groups. After excluding other causes of liverdisease among the NAFLD cohorts (n=210,660), the impact of sex, race and region on outcomes(mortality, discharge disposition, length of stay [LOS], and cost) were computed using generalizedestimating equations (SAS 9.4).Results: Admissions with NAFLD tripled from 2007-2014 at an average rate of 79/100,000hospitalizations/year (P<0.0001), with a larger rate of increase among males vs. females(83/100,000 vs. 75/100,000), Hispanics vs. Whites vs. Blacks (107/100,000 vs. 80/100,000 vs.48/100,000), and government-insured or uninsured patients vs. privately-insured (94/100,000 vs.74/100,000). Males had higher mortality, LOS, and cost than females. Blacks had longer LOS andpoorer discharge destination than Whites; while Hispanics and Asians incurred higher cost thanWhites. Uninsured patients had higher mortality, longer LOS, and poorer discharge dispositionthan the privately-insured.Conclusions: Hospitalizations with NAFLD are rapidly increasing in the US, with adisproportionately higher burden among certain demographic groups. Measures are required toarrest this ominous trend and to eliminate the disparities in outcome among patients hospitalizedwith NAFLD.

Additional Information

Publication

Other

Language: English

Date: 2019

Keywords

Ethnicity, charge, length of stay, cost, discharge disposition

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