Stem cell models of human synapse development and degeneration
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Emily S.,Newell-Litwa,Karen Wilson (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain organoids from human-induced pluripotent stem cells (hIPSC). These hIPSC-derived brain models develop both excitatory and inhibitory synapses and functional synaptic activity. In this review, we address the ability of hIPSC-derived brain models to recapitulate synapse development and insights gained into the molecular mechanisms underlying synaptic alterations in neuronal disorders. We also discuss the potential for more accurate human brain models to advance our understanding of synapse development, degeneration, and therapeutic responses.
Additional Information
- Publication
- Other
- Language: English
- Date: 2018
| Title | Location & Link | Type of Relationship |
| Stem cell models of human synapse development and degeneration | http://hdl.handle.net/10342/7922 | The described resource references, cites, or otherwise points to the related resource. |