Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Emery,Penalver,Manuel,Homesley,Howard,Burrell,Matt A,Rutledge,James,Chernick,Michael,Hallquist,Allan, Salom (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. A prospective, multi-institutional and blinded trial of the assay was conducted in 104 evaluable ovarian cancer patients treated with chemotherapy. The MiCK assay was performed prior to therapy, but treating physicians were not told of the results and selected treatment only on clinical criteria. Outcomes (response, time to relapse, and survival) were compared to the drug-induced apoptosis observed in the assay. The MiCK assay can predict the chemotherapy associated with better outcomes in ovarian cancer patients. This study quantifies outcome benefits on which a prospective randomized trial can be developed.
Additional Information
- Publication
- Other
- Language: English
- Date: 2012
| Title | Location & Link | Type of Relationship |
| Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response | http://hdl.handle.net/10342/7855 | The described resource references, cites, or otherwise points to the related resource. |