Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Paola,Labbozzetta,Manuela,McCubrey,James A.,Ramarosandratana,Aro Vonjy,Sajeva,Maurizio,Zito Poma (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Drug resistance remains a major challenge in the treatment of cancer. The multiplicityof the drug resistance determinants raises the question about the optimal strategies to deal withthem. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils containseveral chemical classes of compounds whose heterogeneity of active moieties can help prevent thedevelopment of drug resistance. In the present paper, we analyzed, by gas chromatography-massspectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensisobtained by hydrodistillation and compared the chemical composition of its essential oil with thatof Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of bothspecies against acute myeloid leukemia on an in vitro model and its multidrug resistant variantinvolving NF-κB pathway. The essential oils of both species produced a significant decrease in manytargets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essentialoils may be a good alternative to traditional drugs in the treatment of cancer, especially in drugresistant cancer.

Additional Information

Publication

Other

Language: English

Date: 2019

Keywords

acute myeloid leukemia cell; Cyphostemma juttae; essential oil; Kalanchoe beharensis; multidrug resistance; NF-κB

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