Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Nam Phong,Shen,Wei,Kratz,Sarah,Vock,Jacqueline,Vos,Pau Nguyen (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Background: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT).Materials and Methods: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted.Results: Acute grade 3--4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2--24 months), no patients developed any radiation related toxicities such as grade 3--4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases.Conclusion: Grade 3--4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3--4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies.

Additional Information

Publication

Other

Language: English

Date: 2013

Keywords

small cell lung cancer, limited stage, chemoradiation, IGRT

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