Attenuated viruses and method of making the same

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Jonathan W. Nyce (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Disclosed are attenuated viruses , not naturally occurring , that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably , the methylation sites are added into the genome of the virus by introducing an additional CG segment into the genome by means of a silent mutation. The attenuated viruses are useful for producing an immune response , including both the production of antibodies in animals for diagnostic use and the induction of protective immunity in a subject. Pharmaceutical formulations and methods of making the attenuated viruses are also disclosed.

Additional Information

Publication

Other

Language: English

Date: 1996

Keywords

virology, modification, immunology

Subjects

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