Attenuated viruses and method of making the same

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Jonathan W. Nyce (Creator)
East Carolina University (ECU )
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Abstract: Disclosed are attenuated viruses , not naturally occurring , that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably , the methylation sites are added into the genome of the virus by introducing an additional CG segment into the genome by means of a silent mutation. The attenuated viruses are useful for producing an immune response , including both the production of antibodies in animals for diagnostic use and the induction of protective immunity in a subject. Pharmaceutical formulations and methods of making the attenuated viruses are also disclosed.

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Language: English
Date: 1996
virology, modification, immunology

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