Measles vaccine vectors and methods of use

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Harriet Robinson (Creator)

Ted Ross (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: The present invention provides a novel vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component , C3d , to enhance the titers of neutralizing antibody. Plasmids were generated that expressed a secreted (s) form of H and the same form fused to three tandem copies of the murine homologue of C3d (sH-3C3d). Analysis of titers of the antibody raised in vaccinated mice indicated that groups vaccinated with the DNA construct expressing sH-3C3d had higher titers of anti-H antibodies compared to serum from mice vaccinated with DNA expressing sH only. In addition , sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation.

Additional Information

Publication

Other

Language: English

Date: 2003

Keywords

immunization, Vaccine

Subjects

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