Hox-gene expression as a biomarker for igf-1r therapeutics
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Fred Edmond Bertrand (Creator)
- Jarrett Thomas Whelan (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: This invention provides methods for treating or preventing the onset of a tumor in a subject , wherein the tumor is determined to overexpress a Hox gene , including administering to the subject a therapeutically or prophylactically effective amount of an insulin-like growth factor-1 receptor (IGF-1R) antagonist. The invention also provides methods for determining whether a tumor in a subject is amenable to treatment with an IGF-1R antagonist including determining whether the tumor overexpresses a Hox gene , wherein overexpression of the Hox gene indicates that the tumor is amenable to treatment with an IGF-1R inhibitor.
Additional Information
- Publication
- Other
- Language: English
- Date: 2008
- Keywords
- cancer, genetics
- Subjects
| Title | Location & Link | Type of Relationship |
| Hox-gene expression as a biomarker for igf-1r therapeutics | http://hdl.handle.net/10342/7536 | The described resource references, cites, or otherwise points to the related resource. |