Low adenosine anti-sense oligonucleotide , compositions , kit and method for treatment of airway disorders associated with bronchoconstriction , lung inflammation , allergy(ies) and surfactant depletion

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Jonathan W. Nyce (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA comprises the topical admistration , e.g. to the respiratory system , of a subject of a therapeutic amount of an oligonucleotide that is antisense to the initiation codon region , coding region , 5' or 3' inton-exon junctions or regions within 2 to 10 nucleotides of the junctions of the target gene , or antisense to a mRNA complementary to the target gene in an amount effective to reach the target polynucleotide and reducing or inhibiting expression. Additionally , a method of treating and adenosine mediated effect is described also utilizing the delivery of antisense and in order to minimize triggering adenosine receptors by their metabolism , the administered oligos have a low content of or are essentially free of adenosine. The agent , composition and formulations are used for prophlactic , preventive and therapeutic treatment of ailments associated with impaired respiration , lung allergies and/or vasoconstriction , inflammation , allergies , allergic rhynitis , asthma , impeded respiration , lung pain , cystic fibrosis and bronchoconstriction.

Additional Information

Publication

Other

Language: English

Date: 2000

Keywords

adenosine, asthma, bronchiodilation

Subjects

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