High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Savanna G Barefoot (Creator)

Patricia M Brophy (Creator)

Angela Clark (Creator)

Gabriel S Dubis (Creator)

Nicole R Gniewek (Creator)

Joseph A Houmard (Creator)

Joshua E McGee (Creator)

Thomas D Raedeke (Creator)

Terence E Ryan (Creator)

Damon L Swift (Creator)

Paul Vos (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Abstract Background African Americans have a disproportionate prevalence and incidence of type 2 diabetes compared with Caucasians. Recent evidence indicates that low cardiorespiratory fitness (CRF) level , an independent risk factor for type 2 diabetes , is also more prevalent in African Americans than Caucasians. Numerous studies in Caucasian populations suggest that vigorous exercise intensity may promote greater improvements in CRF and other type 2 diabetes risk factors (e.g. , reduction of glucose/insulin levels , pulse wave velocity , and body fat) than moderate intensity. However , current evidence comparing health benefits of different aerobic exercise intensities on type 2 diabetes risk factors in African Americans is negligible. This is clinically important as African Americans have a greater risk for type 2 diabetes and are less likely to meet public health recommendations for physical activity than Caucasians. The purpose of the HI-PACE (High-Intensity exercise to Promote Accelerated improvements in CardiorEspiratory fitness) study is to evaluate whether high-intensity aerobic exercise elicits greater improvements in CRF , insulin action , and arterial stiffness than moderate-intensity exercise in African Americans. Methods/Design A randomized controlled trial will be performed on overweight and obese (body mass index of 25-45€‰kg/m2) African Americans (35-65€‰years) (n€‰=€‰60). Participants will be randomly assigned to moderate-intensity (MOD-INT) or high-intensity (HIGH-INT) aerobic exercise training or a non-exercise control group (CON) for 24€‰weeks. Supervised exercise will be performed at a heart rate associated with 45-55% and 70-80% of VO2 max in the MOD-INT and HIGH-INT groups , respectively , for an exercise dose of 600 metabolic equivalents of task (MET)-minutes per week (consistent with public health recommendations). The primary outcome is change in CRF. Secondary outcomes include change in insulin sensitivity (measured via an intravenous glucose tolerance test) , skeletal muscle mitochondrial oxidative capacity (via near-infrared spectroscopy) , skeletal muscle measurements (i.e. , citrate synthase , COX IV , GLUT-4 , CPT-1 , and PGC1-?) , arterial stiffness (via carotid-femoral pulse wave velocity) , body fat , C-reactive protein , and psychological outcomes (quality of life/exercise enjoyment). Discussion The anticipated results of the HI-PACE study will provide vital information on the health effects of high-intensity exercise in African Americans. This study will advance health disparity research and has the potential to influence future public health guidelines for physical activity. Trial registration ClinicalTrials.gov identifier: NCT02892331 . Registered on September 8 , 2016.

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Trials. 2019 Aug 08;20(1):484

Language: English

Date: 2019

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