THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Mohammad Abdulmohsen Alfhili (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the studies presented here , we provide an appraisal of TCS as a chemotherapeutic agent by investigating its influence on the growth and survival of lymphoma cells. We also examine the contribution of TCS to the development of anemia; a major side effect of chemotherapy with a prevalence as high as 90% in cancer patients. Finally , we identify nonionic detergents , often used as excipients in drug formulations , as potent inhibitors of TCS in vivo.

Additional Information

Publication

Dissertation

Language: English

Date: 2019

Keywords

Cancer, Chemotherapy, Apoptosis

Subjects

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