Pulmonary Artery Hemodynamics Using MRI & CFD

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Jake Rabidou (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Pulmonary hypertension (PH) , as defined by a mean pulmonary arterial pressure (mPAP) greater than 25 mmHg , is a life-threatening chronic disorder of the pulmonary circulation which leads to right ventricle failure and if untreated , death. The purpose of this work was to use both , magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) , to quantify changes in wall shear stress (WSS) throughout the pulmonary artery (PA) of a pulmonary hypertension (PH) population when compared to a normotensive control subject. With the future goal of this knowledge potentially being used to diagnose PH non-invasively. Patient's PA's were recreated using MRIs and MIMICS software. Velocity profiles were generated from the MRIs using MATLAB and CFD simulations were conducted using Fluent 17.0. Overall , the data followed a similar trend to published data where the control subject showed an approximately 1.5 to 3.5 times increase in WSS when compared to the PH subjects. The control subject showed a maximum of 5.596 dyn/cm2 while the PH subjects ranged from 1.521 to 3.151 dyn/cm2. This work can serve as the groundwork for further CFD simulations however , future work needs to be done with both a larger population size , potentially modeling further into the pulmonary vasculature as well as attempting different methods of data post-processing.

Additional Information

Publication

Thesis

Language: English

Date: 2017

Keywords

FLUENT, ANSYS, Wall Shear Stress (WSS), mPAP, MRI, Right Heart Catheterization (RHC)

Subjects

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