The Role of Fatty Acid Binding Protein as a Link Between Metabolic Switching and Immune Response in the Macrophage

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Emma Shirley (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Over the last years , there has been unprecedented growth of metabolically-related diseases yet the underlying cellular mechanisms by which each arise is still widely unknown. Recent evidence supports a strong link between the pro-inflammatory response and mechanisms regulating cellular metabolism. This project investigates the role of metabolic factors on the pro-inflammatory response of the macrophage. Macrophages are significant in their heterogeneous phases of activation. Activation change is triggered by cell environment , which is ultimately a product of cell metabolism. The macrophage's metabolic switching combined with its known role in the immune response indicates that a relationship may exist between these two functions. Fatty Acid Binding Protein 5 (FABP5) is exclusive to the macrophage. FABP5 has a known role in fatty acid metabolism but the pathways by which FABP5 connects to the inflammatory response , and thus to disease , is under investigation. We have found through observing changes in gene expression (i.e. Interleukin 12 , IL-12; chemokine ligand 2 , CCL-2; Acyl-CoA Oxidase 1 , AOX; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha , PGC-1?; and Cluster of differentiation 36 , CD36) already known to be connected to metabolism and inflammatory response that FABP is a vital link between metabolic switching and immune response in the macrophage.

Additional Information

Publication

Thesis

Language: English

Date: 2017

Keywords

fatty liver disease, immune response, metabolism, macrophage, liver

Subjects

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