Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Lada N. Alger (Creator)

Stephen W. Davies (Creator)

Jimmy T. Efird (Creator)

T. Bruce Ferguson (Creator)

Whitney L. Kennedy (Creator)

Alan P. Kypson (Creator)

Wesley T. O’Neal (Creator)

Jason B. O’Neal (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Extracted text; Background Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this pooled observational analysis was to compare recent retrospective studies examining long-term survival of patients with multi-vessel coronary artery disease undergoing CABG and PCI. Methodology We searched Medline for observational studies comparing long-term (>1 year) survival between CABG and PCI for the treatment of multi-vessel coronary artery disease over the past 10 years. Results Eight studies met inclusion criteria. A total of 306,868 patients (155,502 CABG; 151,366 PCI) were identified. Follow-up ranged from 1 to 8 years. Mantel-Haenszel combined hazard ratios (HR) for mortality demonstrated a protective benefit of CABG compared with PCI (HR=0.77, 95%CI=0.75–0.79). Conclusion These findings suggest a long-term survival advantage for CABG compared with PCI in patients with multi-vessel coronary artery disease.

Additional Information

Publication

Other

British journal of medicine and medical research; 3:4 p. 1248-1257

Language: English

Date: 2013

Keywords

CABG, long-term, survival, PCI

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