Maternal cadmium, iron and zinc levels, DNA methylation and birth weight

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Thomas Darrah (Creator)

Rebecca Fry (Creator)

Cathrine Hoyo (Creator)

Zhiqing Huang (Creator)

Katherine King (Creator)

Rachel Maguire (Creator)

Susan Murphy (Creator)

Amy Murtha (Creator)

Monica D. Nye (Creator)

Joellen Schildkraut (Creator)

Viktoriya Semenova (Creator)

David Skaar (Creator)

Avner Vengosh (Creator)

Adriana C. Vidal (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Extracted text; Background Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter these outcomes. However mechanisms underlying these relationships remain limited. Methods We examined whether maternal Cd levels during early pregnancy were associated with offspring DNA methylation at regulatory sequences of genomically imprinted genes and weight at birth, and whether Fe and Zn altered these associations. Cd, Fe and Zn were measured in maternal blood of 319 women =12 weeks gestation. Offspring umbilical cord blood leukocyte DNA methylation at regulatory differentially methylated regions (DMRs) of 8 imprinted genes was measured using bisulfite pyrosequencing. Regression models were used to examine the relationships among Cd, Fe, Zn, and DMR methylation and birth weight. Results Elevated maternal blood Cd levels were associated with lower birth weight (p?=?0.03). Higher maternal blood Cd levels were also associated with lower offspring methylation at the PEG3 DMR in females (ß?=?0.55, se?=?0.17, p?=?0.05), and at the MEG3 DMR in males (ß?=?0.72, se?=?0.3, p?=?0.08), however the latter association was not statistically significant. Associations between Cd and PEG3 and PLAGL1 DNA methylation were stronger in infants born to women with low concentrations of Fe (p?

Additional Information

Publication

Other

BMC Pharmacology & Toxicology; 16: p. 1-9

Language: English

Date: 2015

Keywords

Obesity, Pediatrics, Cadmium, Genomic imprinting, Zinc, Epigenetics

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