Control of Vascular Smooth Muscle Cell Growth by Connexin 43

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Chintamani N. Joshi (Creator)

Chaitanya Madamanchi (Creator)

Danielle N. Martin (Creator)

Barbara J. Muller-Borer (Creator)

Patti Shaver (Creator)

David A. Tulis (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Extracted text; Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays important roles in maintaining normal vessel function; however, many of the signaling mechanisms controlling Cx43 in VSMCs are not clearly described. The goal of this study was to investigate mechanisms of Cx43 regulation with respect to VSMC proliferation. Treatment of rat primary VSMCs with the cAMP analog 8Br-cAMP, the soluble guanylate cyclase (sGC) stimulator BAY 41-2272 (BAY), or the Cx inducer diallyl disulfide (DADS) significantly reduced proliferation after 72?h compared with vehicle controls. Bromodeoxyuridine uptake revealed reduction (p?

Additional Information

Publication

Other

Frontiers in Physiology; 3: p. 1-13

Language: English

Date: 2012

Keywords

cGMP, cAMP, protein kinases, Cx43, vascular smooth muscle cells

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