On-Line Adaptive Radiation Therapy: Feasibility and Clinical Study

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

W. Robert Lee (Creator)

Taoran Li (Creator)

Danthai Thongphiew (Creator)

Zeljko Vujaskovic (Creator)

Qiuwen Wu (Creator)

Q. Jackie Wu (Creator)

Fang-Fang Yin (Creator)

Xiaofeng Zhu (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT imaging and fast volumetric reoptimization of treatment plans. A fast intensity-modulated radiotherapy (IMRT) plan reoptimization algorithm is implemented and evaluated with clinical cases. The quality of these adapted plans is compared to the corresponding new plans generated by an experienced planner using a commercial treatment planning system and also evaluated by an in-house developed tool estimating achievable dose-volume histograms (DVHs) based on a database of existing treatment plans. In addition, a clinical implementation scheme for ART is designed and evaluated using clinical cases for its dosimetric qualities and efficiency.

Additional Information

Publication

Other

Journal of Oncology; 2010: p. 1-12

Language: English

Date: 2010

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