KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Shaw M. Akula (Creator)
- Hosni A. M. Hussein (Creator)
- Lia R. Walker (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: main article; Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, KSHV gB is the only glycoprotein known to possess the RGD (Arg-Gly-Asp) binding integrin domain critical to mediating cell attachment. Recent studies described gB to also possess a disintegrin-like domain (DLD) said to interact with non-RGD binding integrins. We wanted to decipher the roles of two individually distinct integrin binding domains (RGD versus DLD) within KSHV gB in regulating attachment of cells over cell migration.
Additional Information
- Publication
- Other
- BMC Cancer; 16: p. 1-17
- Language: English
- Date: 2016
| Title | Location & Link | Type of Relationship |
| KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain | http://hdl.handle.net/10342/5684 | The described resource references, cites, or otherwise points to the related resource. |