Clogging information flow in ALS

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Joseph W. Paul III Coble (Creator)

Aaron D. Gitler Coble (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that causes a progressive loss of motor neurons, leading to paralysis and death typically within 2 to 5 years of onset. There are no cures and few treatments. ALS shares some genetic and pathological overlap with another neurodegenerative disease, frontotemporal dementia (FTD), which causes changes to personality and language. Mutations in the gene called chromosome 9 open reading frame 72 (C9orf72) are the most common genetic cause of both ALS and FTD. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on [Volume 345 on 5 September 2014], DOI: 10.1126/science.1259461.

Additional Information

Publication

Other

Science; 345:6201 p. 1118-1119

Language: English

Date: 2014

Keywords

Proteotoxicity, Frontotemporal dementia, Neurodegeneration, Nucleolus, Human genetics, Amyotrophic lateral sclerosis, ALS, FTD

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