Review: Carbon Nanotubes and Chronic Granulomatous Disease

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Barbara P. Barna (Creator)

Marc A. Judson (Creator)

Mary Jane Thomassen (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles are ubiquitous in non-manufacturing environments and detectable in vapors from diesel fuel, methane, propane, and natural gas. In experimental animal models, carbon nanotubes have been shown to induce granulomas or other inflammatory changes. Evidence suggesting potential involvement of carbon nanomaterials in human granulomatous disease, has been gathered from analyses of dusts generated in the World Trade Center disaster combined with epidemiological data showing a subsequent increase in granulomatous disease of first responders. In this review we will discuss evidence for similarities in the pathophysiology of carbon nanotube-induced pulmonary disease in experimental animals with that of the human granulomatous disease, sarcoidosis.

Additional Information

Publication

Other

Nanomaterials; 4:2 p. 508-521

Language: English

Date: 2014

Keywords

Alveolar macrophages, Carbon nanotubes, Sarcoidosis

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