Systematic review of diagnostic tests for vaginal trichomoniasis.

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

James C. Byrd (Creator)

Carlos A. Estrada (Creator)

Christopher Ohl (Creator)

Sangnya R. Patel (Creator)

Sanjay C. Patel (Creator)

Wilhelmine Wiese (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Objective: To review critically and to summarize the evidence of diagnostic tests and culture media for the diagnosis of Trichomonas vaginitis. Methods: We performed a systematic review of literature indexed in MEDLINE of studies that used Trichomonas culture as the reference standard (9 882 patients 35 studies). Level I studies (5 047 patients 13 studies) fulfilled at least two of three criteria: 1) onsecutive patients were evaluated prospectively 2) decision to culture was not influenced by test results and 3) there was independent and blind comparison to culture. Results: The sensitivity of the polymerase chain reaction technique (PCR) was 95% (95% CI 91% to 99%) and the specificity was 98% (95% CI 96% to 100%). One study was classified as Level I evidence (52 patients). The sensitivity of the enzyme-linked immunosorbent assay was 82% (95% CI 74% to 90%) and the specificity was 73% (95% CI 35% to 100%). The sensitivity of the direct luorescence antibody was 85% (95% CI 79% to 90%) and the specificity was 99% (95% CI 98% to 100%). Sensitivities of culture media were 95% for Diamond’s 96% for Hollander and 95% for PLM. Conclusions: The sensitivity and specificity of tests to diagnose trichomoniasis vary widely. Originally published Infectious Diseases in Obstetrics and Gynecology Vol. 8 No. 5-6 2000

Additional Information

Publication

Other

Infectious Diseases in Obstetrics and Gynecology. 8:5-6(2000) p. 248-257.

Language: English

Date: 2011

Keywords

diagnosis, evidence-based medicine, Meta-analysis, sensitivity and specificity, Trichomonas

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