Racial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian women

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Hisham Barakat (Creator)

Joseph Bower (Creator)

Katherine Cianflone (Creator)

Thea Scantlebury-Manning (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Background: Acylation Stimulating Protein (ASP) has been shown to influence adipose tissue triglyceride (TG) storage. The aim was to examine ethnic differences in ASP and leptin levels in relation to lipid profiles and postprandial changes amongst African American (AA) and Caucasian American (CA) women matched for BMI. Methods: 129 women were recruited in total (age 21 – 73 y): 24 non-obese (BMI < 30 kg/m2) CA 27 obese (BMI ≥ 30 kg/m2) CA 13 obese diabetic CA 25 non-obese AA 25 obese AA and 15 obese diabetic AA. Cholesterol HDL-C LDL-C apoB glucose and insulin were measured at baseline. TG non-esterified fatty acids leptin and ASP were measured at baseline and postprandially following a fat meal. Results: ASP leptin insulin and TG were significantly increased in obese subjects within each race. However AA women had significantly lower ASP and TG than CA women at all BMI. Obese and diabetic AA women had significantly lower apoB levels than CA women when compared to their espective counterparts. For AA women fasting ASP was positively correlated with BMI cholesterol apoB LDL-C and glucose. For CA women fasting ASP was positively correlated with BMI leptin glucose and insulin. However for any given BMI ASP was significantly reduced in AA vs CA (p = 0.0004). Similarly for any given leptin level or TG levels ASP was significantly lower in AA women (p = 0.041 and p = 0.003 respectively). Conclusion: CA women have higher baseline TG levels and an earlier TG peak that is accompanied with higher ASP levels suggesting increased ASP resistance while AA women have ower baseline TG levels and a later TG peak at lower ASP levels suggesting increased ASP sensitivity. This may explain why AA women may have fewer metabolic complications such as diabetes and CVD when compared to their Caucasian counterparts at the same level of obesity. Originally published Nutrition and Metabolism Vol. 6 No. 18 Apr 2009

Additional Information

Publication

Other

Nutrition and Metabolism. 6:18(April 2009) p. 1-9.

Language: English

Date: 2011

Keywords

acylation stimulating protein, trigylceride storage, racial differences

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