Lesional modulation of peripheral monocyte leucotactic responsiveness in leprosy.

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

P. B. Campbell (Creator)

J. L. Krahenbuhl (Creator)

Julie Loesch (Creator)

T. A. Tolson (Creator)

L. Yoder (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Because the accumulation and activation of mononuclear phagocytes are critical to the host response to intracellular microbial pathogens we evaluated mechanisms of peripheral monocyte leucotactic regulation in leprosy. Plasma from 53 of 67 patients was found to inhibit the locomotion of normal human monocytes. Neither the prevalence nor the magnitude of plasma leucotactic inhibitory activity correlated with disease histology or duration type or duration of chemotherapy or history of erythema nodosum leprosum. Plasma leucotactic inhibitory activity resided principally in a non-immunoglobulin cell-directed inhibitor of 230 000 daltons molecular weight. Fractionation of plasma from patients with lepromatous leprosy revealed an additional immunoglobulincontaining inhibitor of approximately 400 000 daltons weight possibly an IgG-IgA immune complex. Production of leucotactic inhibitors by unstimulated and concanavalin A-stimulated peripheral mononuclear cells was normal; however cutaneous explants from these patients spontaneously produced the 230 000 dalton leucotactic inhibitor in vitro. The ability of the lesions of leprosy to impede monocyte traffic may be an important pathogenetic mechanism. Originally published Clinical and Experimental Immunology Vol. 70 No. 2 Nov 1987

Additional Information

Publication

Other

Clinical and Experimental Immunology. 70:2(November 1987) p. 289-297.

Language: English

Date: 2011

Keywords

leprosy, monocytes, leucotaxis, inhibitor

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