C. Jeffrey Smith

There are 9 included publications by C. Jeffrey Smith :

TitleDateViewsBrief Description
Aerobic-Type Ribonucleotide Reductase in the Anaerobe Bacteroides fragilis 2011 65052 Bacteroides fragilis a component of the normal intestinal flora is an obligate anaerobe capable of long-term survival in the presence of air. Survival is attributed to an elaborate oxidative stress response that controls the induction of more than 28...
Analysis of the Zinc Finger Domain of TnpA a DNA Targeting Protein Encoded by Mobilizable Transposon Tn4555 2011 65052 The mobilizable transposon Tn4555 found in Bacteroides spp. is an important antibiotic resistance element encoding a broad spectrum beta-lactamase. Tn4555 is mobilized by conjugative transposons such as CTn341 which can transfer the transposon to a w...
Characterization of Bacteroides fragilis Hemolysins and Regulation and Synergistic Interactions of HlyA and HlyB 2011 65052 This study describes the presence of 10 hemolysin orthologs in the genome of the opportunistic human anaerobic pathogen Bacteroides fragilis which is currently classified as a nonhemolytic bacterium. The hemolysins were designated HlyA through HlyI p...
Cloning and characterization of the endogenous cephalosporinase gene cepA from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases. 2011 65052 Bacteroides frgiglis CS30 is a clinical isolate resistant to high concentrations of benzylpenicillin and cephaloridine but not to cephamycin or penem antibiotics. beta-Lactam resistance is mediated by a chromosomally encoded cephalosporinase produced...
Genetic and biochemical analysis of a novel Ambler class A β-Lactamase responsible for cefoxitin resistance in Bacteroides species. 2011 65052 A clinical isolate of Bacteroides vulgatus was resistant to tetracycline clindamycin ampicillin cephaloridine efoxitin and other 13-lactam antibiotics except imipenem. 13-Lactam resistance was mediated by a membraneassociated lavulanate-sensitive cep...
Identification of a circular intermediate in the transfer and transposition of Tn4555 a mobilizable transposon from Bacteroides spp. 2011 65052 Transmissible cefoxitin (FX) resistance in Bacteroides vulgatus CLA341 was associated with the 12.5-kb obilizable transposon Tn4555 which encoded the 13-lactamase gene cfxA. Transfer occurred by a onjugation-like mechanism was stimulated by growth of...
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates. 2011 65052 Bacteroides fragilis is an important opportunistic pathogen of humans and is resistant to many drugs commonly used to treat anaerobic infections including P-lactams. A strain set comprised of B. fragilis isolates producing either low or high levels o...
Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene cblA encoding the species-specific beta-lactamase. 2011 65052 The gene cbl encoding the species-specific clavulanate-susceptible endogenous cephalosporinase was cloned from Bacteroides uniforinis WAL-7088. The nucleotide sequence was determined and the cbl structural gene was found to be 891 nucleotides with a ...
Oxidative stress response in an anaerobe Bacteroides fragilis: a role for catalase in protection against hydrogen peroxide. 2011 65052 Survival of Bacteroides fragilis in the presence of oxygen was dependent on the ability of bacteria to synthesize ew proteins as determined by the inhibition of protein synthesis after oxygen exposure. The B. fragilis protein rofile was significantly...