Christensen, Tim

ecu

There are 6 item/s.

TitleDateViewsBrief Description
Characterization of Two Novel Mutants of DNA Polymerase Delta in Drosophila melanogaster 2012 95308 DNA is the genetic material for all living organisms which is constantly being unpackaged replicated and repackaged. The replication of this genetic material involves numerous different proteins; however DNA polymerase delta (pol [delta]) carries muc...
Drosophila Ctf4 is essential for genome stability and normal cell cycle progression 2011 95308 Proper DNA replication and well-timed cell cycle progression are vital to the normal functioning of a cell. Precise coordination between these mechanisms' constituent proteins ensures their processivity while safeguarding against DNA damage. The Ctf4...
Drosophila Psf2 Has a Role In Chromosome Condensation 2012 95308 The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability mis-expression of genes and a number of disease states...
ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM 2012 95308 Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS a hetero-tetrameric protein complex is known to be essential for the initiation and progression of eukaryotic DNA replication. The ...
Psf2 a member of the heterotetrameric GINS Complex plays a role in cell cycle progression and maintenance of genomic integrity 2011 95308 Multiple proteins are involved in the complete and accurate replication of the genome during S phase of the cell cycle. At the G1/S phase transition the heterotetrameric GINS complex is recruited to the origin and facilitates the helicase activity of...
Sld5 A Subunit of the Heterotetrameric GINS Complex is Necessary for Normal Cell Cycle Progression and Genomic Stability 2012 95308 Sld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised of multiple subunits: Psf1 ...