| Title | Date | Views | Brief Description |
|---|
| ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM |
2012 |
672387 |
Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS a hetero-tetrameric protein complex is known to be essential for the initiation and progression of eukaryotic DNA replication. The ... |
| Psf2 a member of the heterotetrameric GINS Complex plays a role in cell cycle progression and maintenance of genomic integrity |
2011 |
672387 |
Multiple proteins are involved in the complete and accurate replication of the genome during S phase of the cell cycle. At the G1/S phase transition the heterotetrameric GINS complex is recruited to the origin and facilitates the helicase activity of... |
| Sld5 A Subunit of the Heterotetrameric GINS Complex is Necessary for Normal Cell Cycle Progression and Genomic Stability |
2012 |
672387 |
Sld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised of multiple subunits: Psf1 ... |
| Characterization of Two Novel Mutants of DNA Polymerase Delta in Drosophila melanogaster |
2012 |
672387 |
DNA is the genetic material for all living organisms which is constantly being unpackaged replicated and repackaged. The replication of this genetic material involves numerous different proteins; however DNA polymerase delta (pol [delta]) carries muc... |
| Drosophila Ctf4 is essential for genome stability and normal cell cycle progression |
2011 |
672387 |
Proper DNA replication and well-timed cell cycle progression are vital to the normal functioning of a cell. Precise coordination between these mechanisms' constituent proteins ensures their processivity while safeguarding against DNA damage. The Ctf4... |
| Drosophila Psf2 Has a Role In Chromosome Condensation |
2012 |
672387 |
The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability mis-expression of genes and a number of disease states... |