| Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle |
2011 |
688479 |
Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation however results in disruption of this signal and subsequent insulin resistance. Inflam... |