James A. McCubrey

There are 7 included publications by James A. McCubrey :

TitleDateViewsBrief Description
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer 2011 68075 Background: The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. NIS is expressed in the la...
PKR Regulates B56 alpha-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells 2011 68075 Protein phosphatase 2A (PP2A) is a heterotrimer comprising catalytic scaffold and regulatory (B) subunits. There are at least 21 B subunit family members. Thus PP2A is actually a family of enzymes defined by which B subunit is used. The B56 family me...
Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia 2011 68075 Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2Hindazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) leads to ...
Roles of the RAF/MEK/ERK Pathway in Cell Growth Malignant Transformation and Drug Resistance 2011 68075 Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly expressed in human cancer (e...
Synergistic Proapoptotic Activity of Recombinant Trail Plus the AKT Inhibitor Perifosine in Acute Myelogenous Leukemia Cells 2011 68075 To potentiate the response of acute myelogenous leukemia (AML) cells to TNF-Related Apoptosis- Inducing Ligand (TRAIL) cytotoxicity we have examined the efficacy of a combination with perifosine a novel phosphatidylinositol 3-kinase (PI3K)/Akt signal...
Targeting prostate cancer based on signal transduction and cell cycle pathways 2011 68075 Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent which often occurs after hormonal ablation therapies it is difficult to effectively...
Targeting the RAF/MEK/ERK PI3K/AKT and P53 pathways in hematopoietic drug resistance 2011 68075