Yashomati M. Patel
The long-term goal of my research is to understand the underlying molecular and cellular mechanisms regulating glucose homeostasis as they relate to type 2 diabetes and breast cancer progression. Specifically I am investigating factors involved in the reorganization of the cytoskeleton during glucose transport. The major defect in type 2 diabetes is insulin resistance of peripheral tissues, primarily skeletal muscle and adipose tissue. Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation of insulin-responsive glucose transporter 4 (GLUT4) vesicles from an intracellular pool to the plasma membrane. Identification and characterization of factors involved in glucose uptake is critical for developing more effective treatments for type 2 diabetes. My laboratory has identified myosin II, calpain 10, and naringenin as critical regulators of insulin-stimulated glucose uptake.
There are 3 included publications by Yashomati M. Patel :