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Yashomati M. Patel

The long-term goal of my research is to understand the underlying molecular and cellular mechanisms regulating glucose homeostasis as they relate to type 2 diabetes and breast cancer progression. Specifically I am investigating factors involved in the reorganization of the cytoskeleton during glucose transport. The major defect in type 2 diabetes is insulin resistance of peripheral tissues, primarily skeletal muscle and adipose tissue. Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation of insulin-responsive glucose transporter 4 (GLUT4) vesicles from an intracellular pool to the plasma membrane. Identification and characterization of factors involved in glucose uptake is critical for developing more effective treatments for type 2 diabetes. My laboratory has identified myosin II, calpain 10, and naringenin as critical regulators of insulin-stimulated glucose uptake.

There are 3 included publications by Yashomati M. Patel :

TitleDateViewsBrief Description
Dual Role for Myosin II in GLUT4-Mediated Glucose Uptake in 3T3-L1 Adipocytes 2008 114 Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation and fusion of GLUT4 vesicles to the plasma membrane. Our previous studies demonstrated that GLUT4-mediated glucose uptake is a myosin...
A novel role for myosin II in insulin-stimulated glucose uptake in 3T3-L1 adipocytes 2005 310 Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation and fusion of GLUT4 vesicles from an intracellular pool to the plasma membrane. The studies presented here show that inhibition of my...
Regulation of Myosin Light Chain Kinase during Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes 2013 72 Myosin II (MyoII) is required for insulin-responsive glucose transporter 4 (GLUT4)-mediated glucose uptake in 3T3-L1 adipocytes. Our previous studies have shown that insulin signaling stimulates phosphorylation of the regulatory light chain (RLC) of ...