Influence Of Oncolytic Vesicular Stomatitis Virus On Macrophage Phagocytosis And Breast Cancer Cell Growth In Coculture
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Eliza Grace Watson (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
- Advisor
- Darren Seals
Abstract: This study tested the hypothesis that oncolytic vesicular stomatitis virus could reprogram tumor-promoting M2 THP-1 macrophages into an M1 population capable of suppressing the growth of triple-negative breast cancer cells. While evidence of virus-dependent macrophage reprogramming could be seen via the significant reduction in phagocytosis of latex beads, the growth suppression effects could not be determined in our breast tumor microenvironment-simulating coculture conditions. This was because MDA-MB-231 breast cancer growth was blocked by infection with both wild-type (rwt) and mutant (rM51R-M) VSV strains at all infection ratios tested. These results underscore the substantial oncolytic effects of VSV on an aggressive breast cancer subtype.
Influence Of Oncolytic Vesicular Stomatitis Virus On Macrophage Phagocytosis And Breast Cancer Cell Growth In Coculture
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Created on 2/9/2024
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Additional Information
- Publication
- Thesis
- Watson, E. (2023). Influence Of Oncolytic Vesicular Stomatitis Virus On Macrophage Phagocytosis And Breast Cancer Cell Growth In Coculture. Unpublished Master’s Thesis. Appalachian State University, Boone, NC.
- Language: English
- Date: 2023
- Keywords
- Tumor-Associated Macrophages (TAMs), Vesicular Stomatitis Virus (VSV), Triple-Negative Breast Cancer (TNBC), Oncolytic Virus,
Phagocytosis