Vascular Endothelial Growth Factor Induces Growth Of Uterine Cervix And Immune Cell Recruitment In Mice
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Dr.. Chishimba Nathan Mowa, Associate Professor (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
Abstract: Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on uterine cervical epithelial growth in mice (nonpregnant and pregnant) treated with VEGF agents (recombinant and inhibitor) using a variety of morphological and molecular techniques. Exogenous VEGF altered various uterine cervical epithelial cellular events, including marked induction of growth, edema, increase in inter-epithelial paracellular space, and recruitment of immune cells to the outer surface of epithelial cells (cervical lumen). We conclude that VEGF induces multiple alterations in the uterine cervical epithelial tissues that may play a role in local immune surveillance and uterine cervical growth during CR.
Vascular Endothelial Growth Factor Induces Growth Of Uterine Cervix And Immune Cell Recruitment In Mice
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Additional Information
- Publication
- Chishimba Nathan Mowa, Siobhan M Donnelly, Bao Tran Nguyen, Scott Rhyne, Jordan Estes and Subrina Jesmin (2013) "Vascular Endothelial Growth Factor Induces Growth Of Uterine Cervix And Immune Cell Recruitment In Mice" Journal of Endocrinology vol. 217 Issue 1 pp. 83-94 [DOI: 10.1530/JOE-12-0469] Version of Record Available from (www.joe.endocrinology-journals.org)
- Language: English
- Date: 2013
- Keywords
- VEGF, uterine cervical growth, immune cell recruitment