Dr. Chishimba Nathan Mowa

There are 15 included publications by Dr. Chishimba Nathan Mowa :

TitleDateViewsBrief Description
Antagonism Of Endothelin Action Normalizes Altered Levels Of VEGF And Its Signaling In The Brain Of Stroke-Prone Spontaneously Hypertensive Rat 2007 51 Stroke-prone spontaneously hypertensive rats (SHRSP) often suffer from spontaneous stroke, in part, due to abnormalities in the cerebrovasculature. Here, we investigate the profile of key angiogenic factors and their basic signaling molecules in the ...
Characterization Of Vascular Endothelial Growth Factor (VEGF) “In The Uterine Cervix Over Pregnancy: Effects Of Denervation And Implications For Cervical Ripening 2004 50 Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix- related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in ...
Delineation Of VEGF-Regulated Genes And Functions In The Cervix Of Pregnant Rodents By DNA Microarray Analysis 2008 61 Background: VEGF-regulated genes in the cervices of pregnant and non-pregnant rodents (rats and mice) were delineated by DNA microarray and Real Time PCR, after locally altering levels of or action of VEGF using VEGF agents, namely siRNA, VEGF recept...
Dual Blockade Of Endothelin Action Exacerbates Up-Regulated VEGF Angiogenic Signaling In The Heart Of Lipopolysaccharide-Induced Endotoxemic Rat Model 2016 117 Aims: Sepsis is a cluster of heterogeneous syndromes associated with progressive endotoxemic developments, ultimately leading to damage of multiple organs, including the heart. However, the pathogenesis of sepsis-induced myocardial dysfunction is sti...
Effects Of Protease Activated Receptor (PAR)2 Blocking Peptide On Endothelin-1 Levels In Kidney Tissues In Endotoxemic Rat Model 2014 86 Aims: Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sep...
Endothelin Antagonism Normalizes VEGF Signaling And Cardiac Function In STZ-Induced Diabetic Rat Hearts 2007 70 Abnormal alterations in cardiac expression of vascular endothelial growth factor (VEGF) as well as its receptors and impairment in the development of coronary collaterals have recently been reported in diabetic subjects. However, the presence of phar...
Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-A And -B Messenger Ribonucleic Acid And Protein 2002 65 Body tissues are traditionally classified as estrogen targets based on both the response to the hormone and the presence of estrogen receptors (ERs). We undertook the study on expression of ERff and ERb in the penis to identify compartments/cells res...
Expression Of Pituitary Adenylate Cyclase Activating Peptide In The Uterine Cervix, Lumbosacral Dorsal Root Ganglia And Spinal Cord Of Rats During Pregnancy 2006 88 The uterine cervix is highly innervated by the sensory nerves containing neuropeptides which change during pregnancy and are regulated, in part, by estrogen. These neuropep- tides act as transmitters both in the spinal cord and cervix. The present st...
Expression Of Steroidogenic Enzymes And Synthesis Of Sex Steroid Hormones From DHEA In Skeletal Muscle Of Rats 2007 100 The functional importance of sex steroid hormones (testosterone and estrogens), derived from extragonadal tissues, has recently gained signi?cant appreciation. Circulating dehydroepiandrosterone (DHEA) is peripherally taken up and converted to testos...
Gonadal Hormones And Frontocortical Expression Of Vascular Endothelial Growth Factor In Male Stroke- Prone, Spontaneously Hypertensive Rats, A Model For Attention-Deficit/Hyperactivity Disorder 2004 67 Attention-deficit/hyperactivity disorder (AD/HD) is a common pediatric behavioral disorder associated, in part, with male preponderance and reduced regional cerebral blood flow (rCBF). However, mechanism(s) underlying male preponderance and reduced r...
Landiolol Hydrochloride Ameliorates Acute Lung Injury In A Rat Model Of Early Sepsis Through The Suppression Of Elevated Levels Of Pulmonary Endothelin-1 2016 213 Among the dysfunctions and pathologies associated with sepsis, the underlying molecular mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood. Endothelin (ET)-1, a potent vasoconstrictor and pro-inflammatory peptide, is known to ...
The Penis: A New Target And Source Of Estrogen In Male Reproduction 2006 109 In the past decade, interest and knowledge in the role of estrogen in male reproduction and fertility has gained significant momentum. More recently, the cellular distribution and activity of estrogen receptors (a and ß)(ER) and aromatase (estrogen s...
Postpartum Cervical Repair In Mice: A Morphological Characterization And Potential Role For Angiogenic Factors 2015 63 The cervix undergoes marked mechanical trauma during delivery of the baby at birth. As such, a timely and complete tissue repair postpartum is necessary to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarr...
Substance P In The Uterine Cervix, Dorsal Root Ganglia And Spinal Cord During Pregnancy And The Effect Of Estrogen On SP Synthesis 2003 106 Prior to parturition the non-pliable uterine cervix undergoes a ripening process (“softens” and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence ...
Vascular Endothelial Growth Factor Induces Growth Of Uterine Cervix And Immune Cell Recruitment In Mice 2013 136 Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on ute...